Research & Publications
HOHO Publications
Peer-reviewed publications by the HOHO research team and clinical partners.
37 publications · 4 clinical studies · 5 animal & cell studies · 26 clinical case reports · 2 reviews
Featured Publications
-
20260908Hsiao PJ, Hsu CT, Chiang WF, Chan JS, Huang LY, Yang CC, Lu KC. Molecular hydrogen and the uremic skeleton: a critical review and turnover-state-dependent redox hypothesis in CKD-MBD. Antioxidants (Basel). 2026;15(9):1137.
-
20250810Wu TK, Hsieh YH, Hung TW, Chiou HL, Shih HY, Ting YH, Pan YR, Liu CJ, Kao SH. Coral Hydrate improves renal fibrosis by inhibiting indoxyl sulfate-induced ROS-mediated NLRP3 inflammasome activation. Eur J Pharmacol. 2025;1008:178367.
-
20240620Wu HT, Tsai CS, Chao TH, Ou HY, Tsai LM. A novel antioxidant, hydrogen-rich coral calcium alters gut microbiome and bile acid synthesis to improve methionine-and-choline-deficient diet-induced non-alcoholic fatty liver disease. Antioxidants (Basel). 2024;13(6):746.
Clinical Studies
-
20260416BLiu C, Chen YC, Lu JW, …, Wang KY, Liu FC. Longitudinal in vivo immunophenotyping of regulatory T cells following adjunctive molecular hydrogen therapy in systemic lupus erythematosus. In Vivo. 2026;40(4):2577-88.
-
20250425Lui SW, Hsieh TY, Lu JW, Ho YJ, Liu FC. Predicting therapeutic response to molecular hydrogen in autoimmune diseases via immunophenotyping. APMIS. 2025;133(7):e70040.
-
20240718Lu KC, Shen MC, Wang RL, Chen WW, Chiu SH, Kao YH, Liu FC, Hsiao PJ. Using oral molecular hydrogen supplements to combat microinflammation in humans: a pilot observational study. Int J Med Sci. 2024;21(12):2390-401.
-
20230714BChiu SH, Douglas FL, Chung JR, Wang KY, Chu CF, Chou HY, Huang WC, Wang TY, Chen WW, Shen MC, Liu FC, Hsiao PJ. Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium (HRCC) capsules in patients with metabolic syndrome: a prospective case series study. Front Nutr. 2023;10:1198524.
Animal & Cell Studies
-
20240620Wu HT, Tsai CS, Chao TH, Ou HY, Tsai LM. A novel antioxidant, hydrogen-rich coral calcium alters gut microbiome and bile acid synthesis to improve methionine-and-choline-deficient diet-induced non-alcoholic fatty liver disease. Antioxidants (Basel). 2024;13(6):746.
-
20250810Wu TK, Hsieh YH, Hung TW, Chiou HL, Shih HY, Ting YH, Pan YR, Liu CJ, Kao SH. Coral Hydrate improves renal fibrosis by inhibiting indoxyl sulfate-induced ROS-mediated NLRP3 inflammasome activation. Eur J Pharmacol. 2025;1008:178367.
-
20250721Wu HT, Hsieh MT, Ou HY, Chao TH, Tsai LM. The gastroprotective effect of hydrogen-rich coral calcium in a mouse model of peptic ulcer disease. Drug Des Devel Ther. 2025;19:9845-51.
-
20221111BYang HJ, Tsou WH, Shen MC, Liu CY, Saunders HM, Wang KY, Douglas FL. The effects of hydrogen treatment in a cigarette smoke solution-induced chronic obstructive pulmonary disease-like changes in an animal model. J Thorac Dis. 2022;14(11):4246-55.
-
20220629Wu HT, Chao TH, Ou HY, Tsai LM. Coral Hydrate, a novel antioxidant, improves alcohol intoxication in mice. Antioxidants (Basel). 2022;11(7):1290.
Clinical Case Reports
-
20260327BLin HJ, Lu JW, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. Adjuvant molecular hydrogen facilitates immunosuppressant tapering and sustained remission in systemic lupus erythematosus: a case report. In Vivo. 2026;40(4):2565-76.
-
20260315BWu CL, Lu JW, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. Molecular hydrogen reverses sepsis-induced immunoparalysis: insights from longitudinal deep immunophenotyping. In Vivo. 2026;40(4):2554-64.
-
20260211BLi GL, Lu JW, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. Adjunctive molecular hydrogen capsule therapy in empyema complicated by chronic inflammatory demyelinating polyneuropathy: a case report. In Vivo. 2026;40(3):1832-41.
-
20260124BHsu WH, Lu JW, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. Molecular hydrogen is associated with immunophenotypic modulation and changes in T-cell exhaustion markers in refractory primary Sjögren's syndrome-associated interstitial lung disease: a case report. SAGE Open Med Case Rep. 2026;14:2050313X261454858.
-
20260105Wu CL, Lu JW, Ho YJ, …, Liu FC. Deep immunophenotyping reveals a resilient Tph-ABC axis in difficult-to-treat rheumatoid arthritis: a case report of JAK inhibitor failure complicated by herpes zoster and thrombosis. In Vivo. 2026;40(2):1174-81.
-
20251115BLin CC, Lu JW, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. Adjunctive molecular hydrogen therapy modulates T cell markers and reduces anti-Ro antibody in refractory oral ulcers of Behçet's disease and Sjögren's syndrome: a case report. In Vivo. 2026;40(2):1192-200.
-
20251022Su YS, Lu JW, Ho YJ, …, Liu FC. Longitudinal immune profiling of T cell exhaustion during IL-17A blockade in a patient with HLA-B27-negative spondyloarthritis and Sjögren's syndrome: a case report. In Vivo. 2026;40(1):571-82.
-
20251007BTsai HL, Lu JW, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. Rhupus syndrome with multiple drug intolerances managed by reduced-dose rituximab and adjunctive molecular hydrogen therapy: a case report. In Vivo. 2026;40(1):561-70.
-
20250920BLiu C, Lu JW, Wu CH, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. Adjuvant molecular hydrogen therapy in SLE-associated pulmonary arterial hypertension: a case report on immunomodulatory effects on regulatory and effector lymphocytes. In Vivo. 2026;40(1):551-60.
-
20250722BRen YC, Lu JW, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. A case report of adjuvant molecular hydrogen therapy in refractory rheumatoid arthritis with atlantoaxial subluxation. In Vivo. 2025;39(6):3665-73.
-
20250718BLiu C, Lu JW, Wu CH, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. Dynamic immunomodulation by hydrogen capsule therapy in SLE-associated pulmonary arterial hypertension: a case report. In Vivo. 2025;39(6):3656-64.
-
20250707BHsu NS, Lu JW, Liu HC, Ho YJ, Wang KY, Liu FC. Adjunctive molecular hydrogen therapy for refractory malar rash in systemic lupus erythematosus: a case report with immunological insights. SAGE Open Med Case Rep. 2025;13:2050313X251372755.
-
20250610BChang FH, Lu JW, Hu CC, …, Wang KY, Liu FC. Molecular hydrogen-rhodiola as an adjuvant therapy for ischemic stroke in internal carotid artery occlusion: a case report. Open Med (Wars). 2025;20(1):20251290.
-
20250504BLiu C, Lu JW, Liu HC, Ho YJ, Wang KY, Liu FC. Infective endocarditis and valve surgery in a systemic lupus erythematosus patient following splenectomy: a case report with immunological analysis. In Vivo. 2025;39(5):3025-36.
-
20250414BTu TH, Lu JW, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. Immunomodulatory effects of molecular hydrogen therapy in systemic lupus erythematosus with pericarditis and pleuritis: a case report. In Vivo. 2025;39(5):3014-24.
-
20250328BTsai YH, Lu JW, Tu JI, Li YJ, Hsu HF, Chang FH, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. Molecular hydrogen as an adjuvant therapy in comorbid Sjögren's syndrome, SLE, and ILD: a case report on immune modulation and fatigue reduction. In Vivo. 2025;39(4):2228-35.
-
20250315BTu TH, Lu JW, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. Molecular hydrogen therapy in rheumatoid arthritis: a case report on the amelioration of methotrexate-induced myelosuppression and immune modulation. In Vivo. 2025;39(4):2186-95.
-
20250204BLin YT, Lu JW, Lin JC, Ho YJ, Lui SW, Hsieh TY, Liu HC, Wang KY, Liu FC. Molecular hydrogen capsule therapy for primary biliary cholangitis with elevated IgG4: a case report on immune marker normalization. In Vivo. 2025;39(3):1669-75.
-
20241205BTu TH, Lu JW, Wu CH, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. Molecular hydrogen therapy for SLE-PAH: case report on immune marker modulation. In Vivo. 2025;39(2):1211-9.
-
20241106BLin YT, Lu JW, Ho YJ, Lui SW, Hsieh TY, Liu HC, Wang KY, Liu FC. Molecular hydrogen as an adjuvant therapy in severe lupus serositis with heart failure: a case report on immune modulation and fatigue reduction. In Vivo. 2025;39(2):1200-6.
-
20241031BHsu HF, Hu RY, Lu JW, Hueng DY, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu HC, Liu FC. Molecular hydrogen therapy enhances immune markers in Treg, plasma, Tr1 cells, and KLRG1 expression on Tc cells: a case of acute SDH with midline shift and uncal herniation post-decompressive craniectomy. In Vivo. 2025;39(2):1190-9.
-
20241008BLin YT, Lu JW, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. Molecular hydrogen as a potential adjunctive therapy to improve renal function and reduce fatigue in an elderly patient with chronic comorbidities: a case report. In Vivo. 2025;39(1):572-6.
-
20240903BLin SC, Lu JW, Lin TC, Sung YF, Ho YJ, Wang FM, Lui SW, Hsieh TY, Wang KY, Liu FC. Precision assessment of anti-NMDA receptor encephalitis: a case report on integrating clinical course, immunophenotyping, and comprehensive symptomatology in a pediatric patient with adjunctive hydrogen therapy. In Vivo. 2025;39(1):539-47.
-
20240806Chen JY, Lu JW, Feng SW, Ho YJ, Lui SW, Hsieh TY, Liu FC. Molecular hydrogen therapy in aneurysmal SAH with RA and newly-diagnosed SLE, complicated with acute ischemic infarction: a case report of improved immune markers including Tr1 cells, Breg cells and TIM3 expression on Tc cells. In Vivo. 2024;38(6):3131-7.
-
20240711Lin YT, Lu JW, Wu CH, Ho YJ, Lui SW, Hsieh TY, Liu FC. Molecular hydrogen therapy in Sjögren's syndrome with pulmonary arterial hypertension and right-sided heart failure: a case report of improved immune markers including Treg, B cells and plasma cell. In Vivo. 2024;38(6):3117-24.
-
20240106Lui SW, Lu JW, Ho YJ, Tang SE, Ko KH, Hsieh TY, Liu FC. Molecular hydrogen as a promising therapy could be linked with increased resting Treg cells or decreased Fas+ T cell subsets in a IgG4-PF-ILD patient: a case report. In Vivo. 2024;38(3):1512-8.
Reviews
-
20260908Hsiao PJ, Hsu CT, Chiang WF, Chan JS, Huang LY, Yang CC, Lu KC. Molecular hydrogen and the uremic skeleton: a critical review and turnover-state-dependent redox hypothesis in CKD-MBD. Antioxidants (Basel). 2026;15(9):1137.
-
20240520Zheng CM, Hou YC, Liao MT, Tsai KW, Hu WC, Yeh CC, Lu KC. Potential role of molecular hydrogen therapy on oxidative stress and redox signaling in chronic kidney disease. Biomed Pharmacother. 2024;176:116802.
Publications involving HOHO Biotech’s HRCC hydrogen capsules or collaborating research teams. Case reports describe individual patients and do not establish efficacy. Eight-digit numbers are HOHO reference IDs; B marks publications co-authored by Benson Wang.
Selected Research & References by Others
Independent studies and official sources on molecular hydrogen that we consider important.
International Military & Space Research
-
Military & Aerospace Medicine
National Defense Medical College, Japan: hydrogen reduced behavioral deficits after blast-induced mild traumatic brain injury in mice. Satoh Y, et al. J Neuropathol Exp Neurol. 2018;77(9):827-836. -
Military & Aerospace Medicine
Naval Medical Research Center, U.S. Navy: hydrogen was studied as a deep-diving breathing gas and lowered the risk of decompression sickness in pigs. Kayar SR, et al. J Appl Physiol. 2001;91(6):2713-2719. -
Military & Aerospace MedicineNASA Marshall Space Flight Center, USA: a hypothesis paper proposing therapeutic gases, including hydrogen, as countermeasures to space radiation. Schoenfeld MP, et al. Med Gas Res. 2012;2:8.
-
Military & Aerospace Medicine
University of Defence, Czech Republic: inhaled hydrogen protected the liver against ischemia–reperfusion injury during major surgery in pigs. Malý O, et al. Ann Transl Med. 2019;7(23):774.
Key Mechanism & Physiology
-
MechanismThe energy budget of the human brain. Raichle ME, Gusnard DA. Proc Natl Acad Sci U S A. 2002;99(16):10237-10239.
-
MechanismCognition and mood under simulated combat conditions, U.S. Army. Lieberman HR, et al. Biol Psychiatry. 2005;57(4):422-429.
-
MechanismGut microbiota and intestinal permeability under prolonged military training stress. Karl JP, et al. Am J Physiol Gastrointest Liver Physiol. 2017;312(6):G559-G571.
-
MechanismHydrogen as a selective antioxidant, Nippon Medical School, Japan. Ohsawa I, et al. Nat Med. 2007;13(6):688-694.
Official / Institutional Sources
-
Official Source
Ministry of Economic Affairs, Taiwan: official press release (in Chinese), 19 May 2026, on the results of Taiwanese start-ups at SelectUSA Tech 2026. HOHO’s ration-grade hydrogen capsule for special forces was named one of the Global Top 8 in the Defense Technology category.https://www.moea.gov.tw/Mns/populace/news/News.aspx?kind=1&menu_id=40&news_id=122738
Historical & Review
-
Historical & ReviewBaylor University, USA: the first published therapeutic use of hydrogen; hyperbaric hydrogen led to marked regression of skin squamous cell carcinoma in mice. Dole M, Wilson FR, Fife WP. Science. 1975;190(4210):152-154.
-
Historical & Review
INSERM, Marseille, France: hydrogen breathing reduced fibrosis and increased antioxidant enzyme activity in parasite-induced liver inflammation in mice. Gharib B, et al. C R Acad Sci III. 2001;324(8):719-724. -
Historical & ReviewNippon Medical School, Japan: a review of hydrogen medicine from its origins to its clinical potential. Ohta S. Pharmacol Ther. 2014;144(1):1-11.
This reference list covers research published by other teams and official sources; it is not counted among HOHO’s 37 publications. Institutions are named to show where each study was conducted; inclusion does not imply endorsement of HOHO Biotech by any institution or government.